Extracts and fractions of Gymnema sylvestre restore liver and kidney function by regulating tissue and serum transaminases in the type 2 diabetic rat

Diabetes mellitus usually induce kidney and liver complications, characterized by an increase in transaminases activity. The aim of this study was to evaluate the activity Gymnema sylvestre on variation tissue serum activities high sucrose diet dexamethasone-induced diabetic rats. animals were fed with 20% sugar water for 12 weeks then, received intraperitoneal injection dexamethasone (8mg/kg) once a day 5 days between 07 08 am. After induction, insulin sensitivity test performed divided into 7 groups. experimental groups extracts (aqueous methanolic) fractions (methylene chloride methanol) G. 14 days. At end experiment, sacrificed blood, collected evaluation histopathology reduced plant. negative control (DNC) group 1 had significantly elevated (P<0.001) compared normoglycemic (NNC) different treated This trend also observed at level but only ASAT. Histological analysis revealed hepatic leukocyte infiltrations mesangial expansions urinary space DNC 14. These abnormalities corrected receiving sylvestre. suggests that restore damage